Olanzapine associated diabetes mellitus

Olanzapine associated diabetes mellitus


















Olanzapine associated diabetes mellitus

Recently, a flurry of reports have stated that olanzapine is associated with high blood sugar levels in new onset or pre-existing diabetes mellitus and ketoacidosis,[1–4] which may be reversible after discontinuation of olanzapine. The exact cause of glucose dysregulation by olanzapine is not clear. -. Koller EA, Doraiswamy PM. Author information: Division of Metabolic and Endocrine Drug Products, Center for Drug Evaluation and Review, Food and Drug Administration, Rockville, Maryland, USA. Two hundred thirty-seven patients with -or hyperglycemia. Intervention. One hundred ninety-six cases from January 1994-May 15, 2001, were identified with the United States Food and Drug Administrations MedWatch Drug Surveillance System, and 41 cases published through May 15, 2001, were identified with MEDLINE or This study is a six-week, open label trial of the novel antipsychotic agent, ziprasidone, added to a stable dose of clozapine or in 40 patients, patients with an impaired fasting glucose or insulin resistance with schizophrenia or schizoaffective disorder. In the prevalent-user cohorts, risk was elevated for both and risperidone, but risk with was significantly greater than that with risperidone . Otherwise, there were no significant differences in -related risks for the three medications in any of the analyses. Physicians should consider the risks and benefits when prescribing to patients with an established diagnosis of , or having borderline increased blood glucose level . Patients taking should be monitored regularly for worsening of glucose control. ans clozapine have the highest affinity for H1 receptors and are with the greatest weight gain; ziprasidone and aripiprazole have the lowest affinity for H1 receptors. Some patients develop without concomitant changes in BMI, however; therefore, there must be other possibilities aside from the weight gain. may produce non-trivial high blood sugar in people with . Likewise, the elderly are at

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a greater risk of falls and accidental injury. Likewise, the elderly are at a greater risk of falls and accidental injury. Olanzapine has been associated with insulin resistance and new-onset diabetes mellitus. A 27-year-old African-American man developed new-onset severe hyperglycemia—-glucose 1240 mg/dl, with ketonuria and acidosis, but no weight gain—-2 years after starting olanzapine. is an atypical antipsychotic clinically very effective in the treatment of schizophrenia and related psychoses with better efficacy and tolerability than older generation antipsychotics. Recently there are flurry of reports that is with high blood sugar levels in new onset of or pre-existing Purpose: This study is a diabetes mellitus six-week, open label trial of the novel antipsychotic agent, mellitus ziprasidone, added to a stable dose of clozapine or in 40 patients, patients with an impaired fasting glucose or insulin resistance with schizophrenia or schizoaffective disorder. and ketoacidosis 12 months after starting . Similar cases in the literature were found through a MEDLINE-assisted search using the key words “schizophrenia,” “ melli- Recently, a flurry of reports have stated that is with high blood sugar associated levels in new onset or pre-existing and ketoacidosis, which may be reversible after discontinuation of . More recently, and risperidone , which buy cialis daily collectively account for 80% of all drugs prescribed of their class of atypical antipsychotics, have also been with metabolic abnormalities, though OLZ is generally linked to greater relative risk for and more marked obesity compared with RIS , although a recent report failed to demonstrate an association between weight gain and development of hyperglycemia . In premarketing trials, Eli Lilly reports the incidence of in patients receiving as 0.6%. 10 A postmarketing series documents 139 cases of with therapy, with 14 patients having no predisposing factors . 9 For with , Koller and Doraiswamy reported that 78% of patients had improved glycemic control once was stopped or the dosage decreased; hyperglycemia recurred in 8 of 10 patients when was restarted. OBJECTIVE:To report two cases of new-onset resulting after the initiation of treatment.CASE

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SUMMARY:A 31-year-old African American man and a 44-year-old white man, both with schizoaffective disorder, developed within weeks or months of initiation.DISCUSSION:Our reports of new-onset due to are consistent with those in To quantify the risk of with atypical antipsychotics compared with conventional antipsychotics in managed care Medicaid patients with bipolar disorder. CONCLUSIONS: and risperidone use was with gaining weight in the first year, but only was with developing . Key words risperidone weight gain schizophrenia OBJECTIVE:To report two cases of new-onset resulting after the initiation of treatment.CASE SUMMARY:A 31-year-old African American man and a 44-year-old white man, both with schizoaffective disorder, developed within weeks or months of initiation.DISCUSSION:Our reports of new-onset due to are consistent with those in The antipsychotic medication is with type-2 onset in patients. According to a study from the United States, “This study compared the 1-year incidence of new-onset type-2 and changes in weight in patients with a variety of psychiatric diagnoses prescribed , risperidone, or quetiapine, compared to a reference group receiving The use of , for example, has been with weight gain , exacerbation of previously well controlled , and onset of type I and type II , although a recent report failed to demonstrate an association olanzapine between weight gain and development of hyperglycemia . Two of the cases were - and 4 were clozapine- . Five of our 6 patients had risk factors for , as have 7 of the 9 previously reported in the literature. Purpose: This study is a six-week, open label trial of the novel antipsychotic agent, ziprasidone, added to a stable dose of clozapine or in 40 patients, patients with an impaired fasting glucose or insulin resistance with schizophrenia or schizoaffective disorder. may produce non-trivial high blood sugar in people with . Likewise, the elderly are at a greater risk of falls and accidental injury. Likewise, the elderly are at a greater risk of falls and accidental injury. Hyperglycaemia is listed as an “infrequent” side effect of both and risperidone and as an “infrequent” metabolic and nutritional side effect of risperidone.The degree to which these drugs are with the incidence of has not, however, been established. To quantify the risk of with atypical antipsychotics compared with conventional antipsychotics in managed care Medicaid patients with bipolar disorder. -Induced Pancreatitis: A Case Report Christian Waage 1 , Hans Carlsson 2 , Erik Waage Nielsen 1,3 1 Department of Anesthesiology and 2 Department of Medicine, Nordland Hospital. Jin H, Meyer JM, Jeste DV , Phenomenology of and risk factors for new-onset and diabetic ketoacidosis with atypical antipsychotics: an analysis of 45 published cases.

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